![]() Some people with Proteus syndrome have neurological abnormalities, including intellectual disability, seizures, and vision loss. ![]() Blood vessels (vascular tissue) and fat (adipose tissue) can also grow abnormally in Proteus syndrome. This type of skin growth usually occurs on the soles of the feet and is hardly ever seen in conditions other than Proteus syndrome. The condition can also cause a variety of skin growths, particularly a thick, raised, and deeply grooved lesion known as a cerebriform connective tissue nevus. Bones in the limbs, skull, and spine are often affected. In people with Proteus syndrome, the pattern of overgrowth varies greatly but can affect almost any part of the body. Overgrowth becomes apparent between the ages of 6 and 18 months and gets more severe with age. ![]() Newborns with Proteus syndrome have few or no signs of the condition. The overgrowth is usually asymmetric, which means it affects the right and left sides of the body differently. Organs and tissues affected by the disease grow out of proportion to the rest of the body. Proteus syndrome is a rare condition characterized by overgrowth of the bones, skin, and other tissues.
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